Impurities

Sr No.	Name of Impurity/Ref Standards	CAS No.
A	Apixaban
1	Apixaban Reference Standard	503612-47-3
2	1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one	473927-69-4
3	Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate	27143-07-3
4	Morpholine	110-91-8
5	Valerolactum	675-20-7
6	Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate	503614-91-3
7	1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid	503614-91-3
B	Anagliptin hydrochloride
1	2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid	739364-95-5
2	2-(Boc-oxyimino)-2-phenylacetonitrile	58632-95-4
3	(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile	207557-35-5
4	2-Amino-2-methylpropanenitrile	19355-69-2
C	Azilsartan Kmedoxomil
1	Azilsartan medoxomil	863031-21-4
2	Methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1Hbenzo[d]imidazole-7-carboxylate	139481-44-0
3	3-[(4-{2-[(Z)-N'-hydroxycarbamimidoyl]phenyl}phenyl)methyl]-2-oxo-2,3-dihydro-1H-1,3-benzodiazole-4-carboxylic acid	1821386-21-3
4	methyl 3-((2'-cyanobiphenyl-4-yl)methyl)-2-oxo-2,3-dihydro-1Hbenzo[d]imidazole-4-carboxylate(Impurity I)	139481-33-7
5	methyl 1-((2'-carbamoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate(Impurity A)	147404-76-0
6	(Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1Hbenzo[d]imidazole-7-carboxylic acid(Impurity C)	1397836-49-5
7	methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1Hbenzo[d]imidazole-7-carboxylate(Azilsartan methyl ester)	147403-52-9
8	2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylicacid(Impurity K)	1442400-68-1
9	methyl (Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1Hbenzo[d]imidazole-7-carboxylate(Impurity 2)	147403-65-4
10	2-Ethoxy-1-[[2’-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic Acid(Azilsartan Acid)	147403-03-0
11	methyl 1-((2'-carbamoyl-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate(Impurity A)	1474404-76-0
12	1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1Hbenzo[d]imidazole-7-carboxylic acid(Impurity M)	632322-61-3
13	(Z)-2-ethoxy-1-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-1Hbenzo[d]imidazole-7-carboxylic acid(Impurity C)	1397836-49-5
14	methyl (Z)-3-((2'-(N'-hydroxycarbamimidoyl)-[1,1'-biphenyl]-4-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate(Impurity H)	1499167-72-4
15	methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-4-carboxylate(Impurity J)	1403474-78-1